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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 1
2010 1
2012 1
2015 1
2016 1
2017 1
2019 9
2020 2
2021 1
2022 4
2023 3
2024 0

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26 results

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Page 1
Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?
Urso C. Urso C. Am J Dermatopathol. 2019 Sep;41(9):623-629. doi: 10.1097/DAD.0000000000001341. Am J Dermatopathol. 2019. PMID: 31433323 Review.
In nevi and melanomas, a MAP-kinase pathway activation was generally found, produced by different chromosomal aberrations, including BRAF, NRAS, HRAS, GNAQ, GNA11, BAP1, CTNNB1, MAP2K1, PRKAR1A, and NF1 mutations, and ALK, ROS1, NTRK1, RET, MET, BRAF, NTRK3, and PRKCA fusi …
In nevi and melanomas, a MAP-kinase pathway activation was generally found, produced by different chromosomal aberrations, including BRAF, N …
Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes.
de la Fouchardière A, Pissaloux D, Houlier A, Paindavoine S, Tirode F, LeBoit PE, Bastian BC, Yeh I. de la Fouchardière A, et al. Mod Pathol. 2023 Nov;36(11):100286. doi: 10.1016/j.modpat.2023.100286. Epub 2023 Jul 19. Mod Pathol. 2023. PMID: 37474004
We report the clinical and histologic presentation of 51 cutaneous melanocytic neoplasms with a PKC fusion gene (involving PRKCA in 35 cases, PRKCB in 15 cases, and PRKCG in a single case). ...
We report the clinical and histologic presentation of 51 cutaneous melanocytic neoplasms with a PKC fusion gene (involving PRKCA in 3 …
The role of gene fusions in melanocytic neoplasms.
Quan VL, Panah E, Zhang B, Shi K, Mohan LS, Gerami P. Quan VL, et al. J Cutan Pathol. 2019 Nov;46(11):878-887. doi: 10.1111/cup.13521. Epub 2019 Jun 20. J Cutan Pathol. 2019. PMID: 31152596 Review.
Sporadic cases of pigmented epithelioid melanocytoma may have PRKCA fusions and sheets of monomorphic epithelioid melanocytes. ...
Sporadic cases of pigmented epithelioid melanocytoma may have PRKCA fusions and sheets of monomorphic epithelioid melanocytes. ...
Pigmented Epithelioid Melanocytoma: Morphology and Molecular Drivers.
Benton S, Zhao J, Asadbeigi S, Kim D, Zhang B, Gerami P. Benton S, et al. Surg Pathol Clin. 2021 Jun;14(2):285-292. doi: 10.1016/j.path.2021.01.004. Epub 2021 Apr 28. Surg Pathol Clin. 2021. PMID: 34023106 Review.
Recent advances in molecular analysis have allowed for subclassification of PEM into more specific subsets of melanocytic tumors. The most common subsets include PRKCA fusions, which result in pure PEMs with sheets of monomorphic epithelioid melanocytes, and PEMs with comb …
Recent advances in molecular analysis have allowed for subclassification of PEM into more specific subsets of melanocytic tumors. The most c …
Agminated presentation of fusion-driven melanocytic neoplasms.
Fumero-Velázquez M, Hagstrom M, Dhillon S, Olivares S, Jennings LJ, Dittman D, Sukhanova M, Arva NC, Goldstein SD, Theos A, Pavlidakey P, Carr Z, Gerami P. Fumero-Velázquez M, et al. J Cutan Pathol. 2023 Oct;50(10):913-921. doi: 10.1111/cup.14482. Epub 2023 Jul 5. J Cutan Pathol. 2023. PMID: 37407520
TERT-promoter mutational testing and the melanoma fluorescence in situ hybridization assay were also performed. RESULTS: Three cases were included. Two had a PRKCA fusion (partners ATP2B4 and MPZL1) and one had a ZCCHC8::ROS1 fusion. ...
TERT-promoter mutational testing and the melanoma fluorescence in situ hybridization assay were also performed. RESULTS: Three cases were in …
Targeted Genomic Profiling of Acral Melanoma.
Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. Yeh I, et al. J Natl Cancer Inst. 2019 Oct 1;111(10):1068-1077. doi: 10.1093/jnci/djz005. J Natl Cancer Inst. 2019. PMID: 30657954 Free PMC article.
RESULTS: In addition to BRAF (21.3%), NRAS (27.9%), and KIT (11.5%) mutations, we identified a broad array of MAPK pathway activating alterations, including fusions of BRAF (2.5%), NTRK3 (2.5%), ALK (0.8%), and PRKCA (0.8%), which can be targeted by available inhibitors. I …
RESULTS: In addition to BRAF (21.3%), NRAS (27.9%), and KIT (11.5%) mutations, we identified a broad array of MAPK pathway activating altera …
Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion.
Bahrami A, Lee S, Wu G, Kerstetter J, Rahvar M, Li X, Easton J, Zhang J, Barnhill RL. Bahrami A, et al. JAMA Dermatol. 2016 Mar;152(3):318-22. doi: 10.1001/jamadermatol.2015.2524. JAMA Dermatol. 2016. PMID: 26676968 Free PMC article.
RNA sequencing identified a novel ATPase, Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcript. The fusion resulted in an in-frame linkage of the PRKCA catalytic domain with the N-terminal of ATP2B4 and high expression of the …
RNA sequencing identified a novel ATPase, Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcri …
Identification of key candidate genes involved in melanoma metastasis.
Chen J, Wu F, Shi Y, Yang D, Xu M, Lai Y, Liu Y. Chen J, et al. Mol Med Rep. 2019 Aug;20(2):903-914. doi: 10.3892/mmr.2019.10314. Epub 2019 May 30. Mol Med Rep. 2019. PMID: 31173190 Free PMC article.
The expression levels of PRKCA, BUB1, BAP1 and ASXL1 were significantly different between primary melanoma and metastatic melanoma. ...The involved genes, including PIK3R3, CENPM, AURKA, LAMA1, PCNA, ADCY1, BUB1, NDC80 and PRKCA, and mutation associated genes, inclu …
The expression levels of PRKCA, BUB1, BAP1 and ASXL1 were significantly different between primary melanoma and metastatic melanoma. . …
Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes.
Cohen JN, Joseph NM, North JP, Onodera C, Zembowicz A, LeBoit PE. Cohen JN, et al. Am J Surg Pathol. 2017 Oct;41(10):1333-1346. doi: 10.1097/PAS.0000000000000902. Am J Surg Pathol. 2017. PMID: 28796000
Two of these lesions revealed fusions of the gene encoding the protein kinase C alpha isoform (PRKCA) to 2 distinct partners (ATP2B4-PRKCA and RNF13-PRKCA). Two lesions may represent misdiagnosed "blue nevus with epithelioid features" as they demonstrated GNA …
Two of these lesions revealed fusions of the gene encoding the protein kinase C alpha isoform (PRKCA) to 2 distinct partners (ATP2B4- …
26 results